Anti-Gelsolin GSN Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Gelsolin GSN Rabbit Monoclonal Antibody catalog # M01598. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M01598

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

E3 ubiquitin-protein ligase NEDD4-like;6.3.2.-; NEDD4.2; Nedd4-2; NEDD4L; KIAA0439, NEDL3

Gene Name

GSN

Gene ID

2934

UniProt

P06396

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human Gelsolin.

Clonality

Monoclonal

Clone

Clone: AEHE-7

Tissue Specificity

Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597) . Expressed in melanocytes (PubMed:23999003) . .

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

111932 MW

Observed Molecular Weight

40-48 kDa

Gene Name Synonym

E3 ubiquitin-protein ligase NEDD4-like

Subcellular Location

Cytoplasm . May be recruited to exosomes by NDFIP1.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.