Anti-PEDF Monoclonal Antibody

About this product

Boster Bio Anti-PEDF Monoclonal Antibody catalog # M02034. Tested in WB, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M02034

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1

Gene Name

SERPINF1

Gene ID

5176

UniProt

P36955

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human PEDF Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Clonality

Monoclonal

Clone

Clone: AFED-19

Tissue Specificity

Expression is restricted to melanoma and melanocyte cell lines and retina.

Applications

WB, Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Sensory System, Visual System

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

13157 MW

Observed Molecular Weight

42 kDa

Gene Name Synonym

Melanoma antigen recognized by T-cells 1

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.