- Catalog number
- M00723-1
- Size / count
- 100 µL/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Synonyms
- Forkhead box protein P1; Mac-1-regulated forkhead ; MFH ; FOXP1; HSPC215
- Gene Name
- FOXP1
- Gene ID
- 27086
- UniProt
- Q9H334
- Host
- Rabbit
- Reactivity
- Human, Mouse, Rat
- Immunogen
- A synthesized peptide derived from human FOXP1 Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.
- Clonality
- Monoclonal
- Clone
- Clone: AFFD-6
- Tissue Specificity
- Isoform 8 is specifically expressed in embryonic stem cells. .
- Applications
- WB, IHC, ICC, IF, IP, Flow Cytometry
- Field of Research
- Cancer, Domain Families, Epigenetics and Nuclear Signaling, Forkhead Box, Oncoproteins/Suppressors, Transcription, Tumor Suppressors
- Purification
- Affinity-chromatography
- Concentration
- 0.5mg/ml
- Form
- Liquid
- Function
- Transcriptional repressor (PubMed:18347093) . Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity) . Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T (FH) s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity) . Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198) . Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093) . Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716) . Can negatively regulate androgen receptor signaling (PubMed:18640093) . .
- Storage Conditions
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 75317 MW
- Observed Molecular Weight
- 90 kDa
- Gene Name Synonym
- Forkhead box protein P1
- Subcellular Location
- Nucleus .
- Protein Name
- T-cell surface glycoprotein CD4
- Isotype
- Rabbit IgG
- Contents
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
