Anti-ADAMTS13 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-ADAMTS13 Rabbit Monoclonal Antibody catalog # M00586-1. Tested in WB, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M00586-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Serine/threonine-protein kinase ULK1;2.7.11.1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1; ULK1; KIAA0722

Gene Name

ADAMTS13

Gene ID

11093

UniProt

Q76LX8

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human ADAMTS13

Clonality

Monoclonal

Clone

Clone: 20A01

Tissue Specificity

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Applications

WB, Flow Cytometry

Field of Research

Cardiovascular, Metabolism, Mitochondrial Metabolism, Neurogenesis, Neurology Process, Neuroscience, Pathways and Processes, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

112631 MW

Observed Molecular Weight

154 kDa

Gene Name Synonym

Serine/threonine-protein kinase ULK1

Subcellular Location

Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .

Protein Name

T-cell surface glycoprotein CD4

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.