Anti-TBX21 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-TBX21 Rabbit Monoclonal Antibody catalog # M00404-1. Tested in IHC application. This antibody reacts with Human.

Specifications

Catalog number

M00404-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

NADPH oxidase 4;1.6.3.-; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD (P) H-oxidase; NOX4; RENOX

Gene Name

TBX21

Gene ID

30009

UniProt

Q9UL17

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human T-bet / Tbx21

Clonality

Monoclonal

Clone

Clone: 20T77

Tissue Specificity

Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level) . Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. .

Applications

IHC

Field of Research

Adaptive Immunity, B Cells, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Immunology, Non-CD, Stem Cells, Surface Molecules, T Cells, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

66932 MW

Observed Molecular Weight

52 kDa

Gene Name Synonym

NADPH oxidase 4

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cell junction, focal adhesion . May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.

Protein Name

T-cell surface glycoprotein CD4

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.