Anti-SQSTM1 / p62 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-SQSTM1 / p62 Rabbit Monoclonal Antibody catalog # M00300-3. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M00300-3

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA, OSIL

Gene Name

SQSTM1

Gene ID

8878

UniProt

Q13501

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human SQSTM1 / p62

Clonality

Monoclonal

Clone

Clone: 21S51

Tissue Specificity

Ubiquitously expressed. .

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Cancer, Cardiovascular, Cell Death, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, NFKB Pathway, Nuclear Signaling, Pathways and Processes, Pol II Transcription, Polymerase Associated Factors, Protein Trafficking, Signal Transduction, Signaling Pathway, Transcription, Vesicle Transport

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Autophagy receptor that interacts ly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity) . May be involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

47687 MW

Observed Molecular Weight

62 kDa

Gene Name Synonym

Sequestosome-1

Subcellular Location

Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Sarcomere (By similarity) . In cardiac muscles localizes to the sarcomeric band (By similarity) . Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. .

Protein Name

P2X purinoceptor 1

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.