Anti-SPINK1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-SPINK1 Rabbit Monoclonal Antibody catalog # M00982. Tested in WB, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

M00982

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100B

Gene Name

SPINK1

Gene ID

6690

UniProt

P00995

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human SPINK1

Clonality

Monoclonal

Clone

Clone: 22S26

Tissue Specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Applications

WB, IHC

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling, Neural Stem Cells, Stem Cells

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

10713 MW

Observed Molecular Weight

11 kDa

Gene Name Synonym

Protein S100-B

Subcellular Location

Cytoplasm . Nucleus .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.