Anti-IL7R alpha/CD127 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-IL7R alpha/CD127 Rabbit Monoclonal Antibody catalog # M02222. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M02222

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

CD276 antigen;4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276; CD276; B7H3; PSEC0249, UNQ309/PRO352

Gene Name

IL7R

Gene ID

3575

UniProt

P16871

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human IL7R alpha/CD127

Clonality

Monoclonal

Clone

Clone: 22I71

Tissue Specificity

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. .

Applications

WB, IHC, Flow Cytometry

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurogenesis, Neurology Process, Neuroscience, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

52 kDa

Observed Molecular Weight

75 kDa

Gene Name Synonym

CD276 antigen

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.