Anti-DNA Polymerase gamma Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-DNA Polymerase gamma Rabbit Monoclonal Antibody catalog # M02796. Tested in WB application. This antibody reacts with Human.

Specifications

Catalog number

M02796

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone-lysine N-methyltransferase SETD7;2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9; SETD7; KIAA1717, KMT7, SET7, SET9

Gene Name

POLG

Gene ID

5428

UniProt

P54098

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human DNA Polymerase gamma

Clonality

Monoclonal

Clone

Clone: 24P93

Tissue Specificity

Widely expressed. Expressed in pancreatic islets.

Applications

WB

Field of Research

2339, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Methylation

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40721 MW

Observed Molecular Weight

140 kDa

Gene Name Synonym

Histone-lysine N-methyltransferase SETD7

Subcellular Location

Nucleus. Chromosome .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.