Anti-Phospho-PDHA1 (S293) Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Phospho-PDHA1 (S293) Rabbit Monoclonal Antibody catalog # P01906. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

P01906

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Phospho Site

S293

Synonyms

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha;3.1.3.16; Replication protein C; RP-C; PPP2CA

Gene Name

PDHA1

Gene ID

5160

UniProt

P08559

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Phospho-PDHA1 (S293)

Clonality

Monoclonal

Clone

Clone: 25P34

Tissue Specificity

Expressed in brain, and to a lesser extent in lung, kidney and testis.

Applications

WB, IHC, IP

Field of Research

Cancer, Cardiovascular, Cell Biology, Cell Cycle, Contractility, Cytoplasmic, Epigenetics and Nuclear Signaling, Intracellular Signaling, Kinases/Phosphatases, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Phosphatases, Signal Transduction, Signaling Pathways, Stem Cells, TGF Beta

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs) . PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity) . Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35594 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Subcellular Location

Cytoplasm . Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity) . .

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.