Anti-PROS1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-PROS1 Rabbit Monoclonal Antibody catalog # M01568. Tested in WB application. This antibody reacts with Human.

Specifications

Catalog number

M01568

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta;2.7.11.1; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1; BUB1B; BUBR1, MAD3L, SSK1

Gene Name

PROS1

Gene ID

5627

UniProt

P07225

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human PROS1

Clonality

Monoclonal

Clone

Clone: 25P82

Tissue Specificity

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. .

Applications

WB

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Division, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Spindle

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

119545 MW

Observed Molecular Weight

75 kDa

Gene Name Synonym

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Subcellular Location

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.