Anti-TMF Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-TMF Rabbit Monoclonal Antibody catalog # M02214. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Specifications

Catalog number

M02214

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Caspase-10; CASP-10;3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP10; MCH4

Gene Name

TMF1

Gene ID

7110

UniProt

P82094

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TMF

Clonality

Monoclonal

Clone

Clone: 30T88

Tissue Specificity

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Applications

WB, ICC, IF

Field of Research

Adaptive Immunity, Alzheimer's Disease, Cancer, Cell Biology, Cell Cycle, Cell Division, Chromatin Remodeling, Chromosome Structure, Epigenetics and Nuclear Signaling, ER Proteins, Immunology, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Protein Trafficking, Ser/Thr Phosphatases, Signal Transduction, T Cells

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

58951 MW

Observed Molecular Weight

160 kDa

Gene Name Synonym

Caspase-10

Subcellular Location

Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity) . .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.