Recombinant Human FGF2 Protein

About this product

Fibroblast Growth Factor basic (FGF-basic/FGF-2) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF (keratinocyte growth factor = FGF-7) . All factors are products of different genes, some of which are Oncogene products (FGF-3, FGF-4, FGF-5) .

Specifications

Catalog number

R00121

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Gene Name

FGF2

Gene ID

2247

UniProt

P09038

Reactivity

Human

Source

E. Coli-derived P143-S288

Purification

>95%, by SDS-PAGE quantitative densitometry by Coomassie? Blue Staining.

Endotoxin

Less than 1 EU/μg of rHubFGF as determined by LAL method.

Form

Lyophilized

Storage Conditions

Lyophilized recombinant mouse Fibroblast Growth Factor basic (FGF-basic/FGF-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF2 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Calculated Molecular Weight

16.5KD

AA Sequence

PALPE DGGSG AFPPG HFKDP KRLYC KNGGF FLRIH PDGRV DGVRE KSDPH IKLQL QAEER GVVSI KGVCA NRYLA MKEDG RLLAS KCVTD ECFFF ERLES NNYNT YRSRK YTSWY VALKR TGQYK LGSKT GPGQK AILFL PMSAK S

Contents

Lyophilized after extensive dialysis against PBS.