Recombinant Human OSM Protein

About this product

Oncostatin-M (OSM) is amember of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophagecolony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Specifications

Catalog number

R00804

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Gene Name

OSM

Gene ID

5008

UniProt

P13725

Reactivity

Human

Source

E. coli A26-R221

Purification

>95%, by SDS-PAGE quantitative densitometry by Coomassie? Blue Staining.

Endotoxin

Less than 1 EU/μg of OSM as determined by LAL method.

Form

Lyophilized

Storage Conditions

Lyophilized recombinant human Oncostatin-M remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, OSM remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Calculated Molecular Weight

22KD

AA Sequence

AAIGS CSKEY RVLLG QLQKQ TDLMQ DTSRL LDPYI RIQGL DVPKL REHCR ERPGA FPSEE TLRGL GRRGF LQTLN ATLGC VLHRL ADLEQ RLPKA QDLER SGLNI EDLEK LQMAR PNILG LRNNI YCMAQ LLDNS DTAEP TKAGR GASQP PTPTP ASDAF QRKLE GCRFL HGYHR FMHSV GRVFS KWGES PNRSR

Contents

Reconstitute in ddH2O at 100 μg/mL.