Recombinant Human IFN gamma Protein

About this product

Interferon gamma (IFNγ ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulatedwith phytohemagglutinin, and by others as a productofantigen-stimulatedlymphocytes ortuberculin-sensitized mouseperitoneal lymphocytes challenged with PPD.The resulting supernatants were shown toinhibit growth of vesicular stomatitisvirus. IFNγ is a cytokine that is critical for innate and adaptive immunityagainst viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication ly, and most importantly from its immunostimulatoryand immunomodulatoryeffects. IFNγ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.

Specifications

Catalog number

R00393

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Gene Name

IFNG

Gene ID

3458

UniProt

P01579

Reactivity

Human

Source

E. coli Gln24-Gly161

Purification

>95%, by SDS-PAGE quantitative densitometry by Coomassie? Blue Staining.

Endotoxin

Less than 1 EU/μg of IFNγ as determined by LAL method.

Form

Lyophilized

Storage Conditions

Lyophilized recombinant human Interferon gamma remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIFNγremains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Calculated Molecular Weight

16.1KD

AA Sequence

QDPYV KEAEN LKKYF NAGHS DVADN GTLFL GILKN WKEES DRKIM QSQIV SFYFK LFKNF KDDQS IQKSV ETIKE DMNVK FFNSN KKKRD DFEKL TNYSV TDLNV QRKAI HELIQ VMAEL SPAAK TGKRK RSQML FRG

Contents

Reconstitute in ddH2O at 100 μg/mL.