Anti-MIB2 Antibody Picoband®

About this product

Boster Bio Anti-MIB2 Antibody Picoband® catalog # A07098-1. Tested in WB, IP, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07098-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.

Synonyms

MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1

Gene Name

MIB2

Gene ID

142678

UniProt

Q96AX9

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MIB2 recombinant protein (Position: A71-I572) . Human MIB2shares 90.3% and 89.7% amino acid (aa) sequence identity with mouse and rat MIB2, respectively.

Clonality

Polyclonal

Applications

WB, IP, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Feltham, R., Jamal, K., Tenev, T., Liccardi, G., Jaco, I., Domingues, C. M., Morris, O., John, S. W., Annibaldi, A., Widya, M., Kearney, C. J., Clancy, D., and 10 others. Mind bomb regulates cell death during TNF signaling by suppressing RIPK1's cytotoxic potential. Cell Rep. 23: 470-484, 2018. 2. Koo, B.-K., Yoon, K.-J., Yoo, K.-W., Lim, H.-S., Song, R., So, J.-H., Kim, C.-H., Kong, Y.-Y. Mind bomb-2 is an E3 ligase for Notch ligand. J. Biol. Chem. 280: 22335-22342, 2005. 3. Piccolo, P., Attanasio, S., Secco, I., Sangermano, R., Strisciuglio, C., Limongelli, G., Miele, E., Mutarelli, M., Banfi, S., Nigro, V., Pons, T., Valencia, A., and 12 others. MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation /non-compaction and are associated with Menetrier-like gastropathy. Hum. Molec. Genet. 26: 33-43, 2017.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

110 kDa

Observed Molecular Weight

110 kDa

Applications Notes

6

Gene Name Synonym

MIB E3 ubiquitin protein ligase 2

Protein Name

E3 ubiquitin-protein ligase MIB2

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.