Anti-MYOF Antibody Picoband®

About this product

Boster Bio Anti-MYOF Antibody Picoband® catalog # A04580-1. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04580-1-carrier-free

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.

Synonyms

MYOF; FER1L3; KIAA1207; Myoferlin; Fer-1-like protein 3

Gene Name

MYOF

Gene ID

26509

UniProt

Q9NZM1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MYOF recombinant protein (Position: E175-E2003) . Human MYOF shares 93.9% amino acid (aa) sequence identity with mouse MYOF.

Clonality

Polyclonal

Applications

WB, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Ariano, A., D'Apolito, M., Bova, M., Bellanti, F., Loffredo, S., D'Andrea, G., Intrieri, M., Petraroli, A., Maffione, A. B., Spadaro, G., Santacroce, R., Margaglione, M. A myoferlin gain-of-function variant associates with a new type of hereditary angioedema. (Letter) Allergy 75: 2989-2992, 2020. 2. Britton, S., Freeman, T., Vafiadaki, E., Keers, S., Harrison, R., Bushby, K., Bashir, R. The third human FER-1-like protein is highly similar to dysferlin. Genomics 68: 313-321, 2000. 3. Davis, D. B., Delmonte, A. J., Ly, C. T., McNally, E. M. Myoferlin, a candidate gene and potential modifier of muscular dystrophy. Hum. Molec. Genet. 9: 217-226, 2000.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

235 kDa

Observed Molecular Weight

250 kDa

Gene Name Synonym

Myoferlin

Protein Name

Myoferlin

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.