Anti-GABBR2 Antibody Picoband®

About this product

Boster Bio Anti-GABBR2 Antibody Picoband® catalog # A03830-2. Tested in WB, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A03830-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Synonyms

GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20

Gene Name

GABBR2

Gene ID

9568

UniProt

O75899

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GABBR2 recombinant protein (Position: D100-Q889) . Human GABBR2 shares 98.4% and 98.1% amino acid (aa) sequence identity with mouse and rat GABBR2, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Beuten, J., Ma, J. Z., Payne, T. J., Dupont, R. T., Crews, K. M., Somes, G., Williams, N. J., Elston, R. C., Li, M. D. Single- and multilocus allelic variants with the GABA (B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am. J. Hum. Genet. 76: 859-864, 2005. 2. Clark, J. A., Mezey, E., Lam, A. S., Bonner, T. I. Distribution of the GABA-B receptor subunit gb2 in rat CNS. Brain Res. 860: 41-52, 2000. 3. EuroEPINOMICS-RES Consortium, Epilepsy Phenome/Genome Project, Epi4K Consortium. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. Am. J. Hum. Genet. 95: 360-370, 2014. Note: Erratum: Am. J. Hum. Genet. 100: 179 only, 2017.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

106 kDa

Observed Molecular Weight

106 kDa

Gene Name Synonym

Gamma-aminobutyric acid type B receptor subunit 2

Protein Name

Gamma-aminobutyric acid type B receptor subunit 2

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.