Anti-ADAM12 Antibody Picoband®

About this product

Boster Bio Anti-ADAM12 Antibody Picoband® catalog # A02264-2. Tested in WB, IHC, IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02264-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.

Synonyms

ADAM12; MLTN; UNQ346/PRO545; Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; EC 3.4.24.-; Meltrin-alpha

Gene Name

ADAM12

Gene ID

8038

UniProt

O43184

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human ADAM12 recombinant protein (Position: V31-K476) . Human ADAM12 shares 79.1% amino acid (aa) sequence identity with mouse ADAM12.

Clonality

Polyclonal

Applications

WB, IHC, IF, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Galliano, M.-F., Huet, C., Frygelius, J., Polgren, A., Wewer, U. M., Engvall, E. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion. J. Biol. Chem. 275: 13933-13939, 2000. 2. Gilpin, B. J., Loechel, F., Mattei, M.-G., Engvall, E., Albrechtsen, R., Wewer, U. M. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J. Biol. Chem. 273: 157-166, 1998. 3. Kurisaki, T., Masuda, A., Sudo, K., Sakagami, J., Higashiyama, S., Matsuda, Y., Nagabukuro, A., Tsuji, A., Nabeshima, Y., Asano, M., Iwakura, Y., Sehara-Fujisawa, A. Phenotypic analysis of meltrin alpha (ADAM12) -deficient mice: involvement of meltrin alpha in adipogenesis and myogenesis. Molec. Cell. Biol. 23: 55-61, 2003.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

100 kDa

Observed Molecular Weight

90 kDa

Applications Notes

6

Gene Name Synonym

ADAM metallopeptidase domain 12

Protein Name

Disintegrin and metalloproteinase domain-containing protein 12

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.