Anti-XPG/ERCC5 Antibody Picoband®

About this product

Boster Bio Anti-XPG/ERCC5 Antibody Picoband® catalog # A01770-2. Tested in WB, IHC, IF, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01770-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Synonyms

ERCC5; ERCM2; XPG; XPGC; DNA repair protein complementing XP-G cells; EC 3.1.-.-; DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein

Gene Name

ERCC5

Gene ID

2073

UniProt

P28715

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human XPG/ERCC5 recombinant protein (Position: K115-R964) . Human XPG/ERCC5 shares 66.6% amino acid (aa) sequence identity with mouse XPG/ERCC5.

Clonality

Polyclonal

Applications

WB, IHC, IF, ICC/IF, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Arlett, C. F., Harcourt, S. A., Lehman, A. R., Stevens, S., Ferguson-Smith, M. A., Morley, W. N. Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation. Carcinogenesis 1: 745-751, 1980. 2. Cheesbrough, M. J. Xeroderma pigmentosum--a unique variant with neurological involvement. Brit. J. Derm. 99 (Suppl. 16) : 61 only, 1978. 3. Cleaver, J. E., Thompson, L. H., Richardson, A. S., States, J. C. A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Hum. Mutat. 14: 9-22, 1999.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

133 kDa

Observed Molecular Weight

200 kDa

Applications Notes

6

Gene Name Synonym

ERCC excision repair 5, endonuclease

Protein Name

DNA excision repair protein ERCC-5

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.