Anti-p16 Cdkn2a Antibody

About this product

Boster Bio Anti-p16 Cdkn2a Antibody (Catalog # A00016) . Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

A00016

Size / count

100 µL

Dry ice

Yes

Hazardous

No

Discontinued

No

Background

The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene (isoform 4 a.k.a. p14ARF, p19ARF, ARF) . In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.

Synonyms

P16, Cyclin-dependent kinase inhibitor 2A isoforms 1/2/, Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, p16INK4A, p16-INK4, Multiple tumor suppressor 1, MTS-1, CDKN2, MTS1

Gene Name

CDKN2A

UniProt

P42771

Host

Rabbit

Reactivity

Human

Immunogen

Human p16 protein (missing the first 7 amino acids)

Clonality

Polyclonal

Applications

ELISA, IHC, IP, WB

Field of Research

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, p53 Pathway, Transcription, Tumor Suppressors

Purification

This product was prepared from monospecific antiserum by delipidation and defibrination. Antiserum will specifically react with a p16 protein from human tissue. Cross-reactivity may occur with p15 when immunoprecipitating in vitro translated product but not in immunoblots. Potentially cross reacts with p15.5.

Concentration

85 mg/mL by Refractometry

Form

Liquid (sterile filtered)

Shipping Conditions

Dry Ice Shipping

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Isotype

Antiserum

Contents

0.01% (w/v) Sodium Azide