Anti-CXCR4 (phospho-S339) Antibody

About this product

Boster Bio Anti-CXCR4 (phospho-S339) Antibody catalog # A00031S339. Tested in WB applications. This antibody reacts with Human.

Specifications

Catalog number

A00031S339

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR

Gene Name

CXCR4

UniProt

P61073

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Serine 339.

Clonality

Polyclonal

Tissue Specificity

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431) . Involved in the AKT signaling cascade (PubMed:24912431) . Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524) . Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059) . Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205) . Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal- neuron survival (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

39746 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

C-X-C chemokine receptor type 4

Subcellular Location

Cell membrane

Protein Name

C-X-C chemokine receptor type 4

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2