Anti-Bcl-2 (phospho-T56) Antibody

About this product

Boster Bio Anti-Bcl-2 (phospho-T56) Antibody catalog # A00040T56. Tested in IHC, IP, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00040T56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Apoptosis regulator Bcl-2; BCL2

Gene Name

BCL2

UniProt

P10415

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 56.

Clonality

Polyclonal

Tissue Specificity

Expressed in a variety of tissues.

Applications

IHC, IP, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

26266 MW

Gene Name Synonym

Apoptosis regulator Bcl-2

Subcellular Location

Mitochondrion outer membrane

Protein Name

Apoptosis regulator Bcl-2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2