Anti-HP Antibody (Center)

About this product

Boster Bio Anti-HP Antibody (Center) (Catalog # A00062-3) . Tested in IHC-P-Leica, WB, IF, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

A00062-3-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP

Gene Name

HP

UniProt

P00738

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

IHC-P-Leica, WB, IF, Flow Cytometry

Field of Research

Cardiovascular, Cell Biology, Signal Transduction, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

45205 Da

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.