Anti-LDL-R Antibody

About this product

Boster Bio Anti-LDL-R Antibody (Catalog # A00076) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00076

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Synonyms

FH, FHC, LDLCQ2, Low-density lipoprotein receptor, LDL receptor

Gene Name

LDLR

UniProt

P01130

Host

Chicken

Reactivity

Human, Mouse, Rat

Immunogen

LDL-R antibody was raised against an 18 amino acid synthetic peptide near the center of human LDL-R. The immunogen is located within amino acids 490 - 540 of LDL-R.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Obesity

Purification

LDL-R Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Storage Conditions

LDL-R antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

95376 MW

Gene Name Synonym

Low density lipoprotein receptor

Subcellular Location

Cell membrane

Prediction Reactivity

Pig, Rabbit

Protein Name

Low density lipoprotein receptor

Isotype

IgY

Contents

LDL-R Antibody is supplied in PBS containing 0.02% sodium azide.