Anti-NOD2 (Card15) Antibody

About this product

Boster Bio Anti-NOD2 (Card15) Antibody (Catalog# A00087) . Tested in WB, IHC, IP application (s) . This antibody reacts with Human.

Specifications

Catalog number

A00087

Size / count

50 μL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NOD2; CARD15, IBD1

Gene Name

NOD2

UniProt

Q9HC29

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide of human NOD2/CARD15 (amino acids 582-600 LGFLVRAKGVVPGSTAPLE)

Clonality

Polyclonal

Tissue Specificity

Monocytes-specific.

Applications

WB, IHC, IP

Field of Research

Apoptosis, Caspases, Cell Biology, Intracellular

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561) . .

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Observed Molecular Weight

115283 MW

Gene Name Synonym

Nucleotide-binding oligomerization domain-containing protein 2

Subcellular Location

Cytoplasm. Membrane. Basolateral cell membrane.

Protein Name

Nucleotide-binding oligomerization domain-containing protein 2

Isotype

Rabbit IgG

Contents

50 μ l sera