Anti-Transcription factor SOX-2 SOX2 Antibody

About this product

Boster Bio Anti-Transcription factor SOX-2 SOX2 Antibody (Catalog # A00105) . Tested in ELISA, WB, ICC, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00105

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction.

Synonyms

ANOP3, MCOPS3, Transcription factor SOX-2

Gene Name

SOX2

UniProt

P48431

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

SOX2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SOX. The immunogen is located within the first 50 amino acids of SOX2.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IHC-P, IF

Field of Research

Homeostasis, Stem Cells

Purification

SOX2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) .

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

34310 MW

Gene Name Synonym

SRY (sex determining region Y) -box 2

Subcellular Location

Nucleus.

Prediction Reactivity

Sheep, Chicken, Horse, Pig

Protein Name

SRY (sex determining region Y) -box 2

Isotype

IgG

Contents

SOX2 Antibody is supplied in PBS containing 0.02% sodium azide.