Anti-SRC Antibody (N-term)

About this product

Boster Bio Anti-SRC Antibody (N-term) (Catalog # A00107) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

A00107-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The gene for SRC is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. SRC, the protein encoded by this gene, is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in SRC could be involved in the malignant progression of colon cancer.

Synonyms

Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src, SRC, SRC1

Gene Name

SRC

UniProt

P12931

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SRC.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues [Isoform 2]: Expressed in brain.

Applications

WB, IF, IHC-P

Field of Research

Cancer, Signal Transduction, Host-Virus Interaction, Immunology, Chemokine signaling, Mitochondria

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

59835 Da

Subcellular Location

Cell membrane; Lipid-anchor. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) . Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268) . Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596)

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.