Anti-Matrix metalloproteinase-9 MMP9 Antibody

About this product

Boster Bio Anti-Matrix metalloproteinase-9 MMP9 Antibody (Catalog # A00139) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00139

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The matrix metalloproteinase (MMP) family are a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases (1) . MMP9 degrades type IV and V collagens (2) and studies suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow (3) and plays a role in tumor-associated tissue remodeling (4) .

Synonyms

GELB, CLG4B, MMP-9, MANDP2, Matrix metalloproteinase-9, 92 kDa gelatinase

Gene Name

MMP9

UniProt

P14780

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

MMP9 antibody is human, mouse and rat reactive. At least three isoforms of MMP9 are known to exist; this antibody only recognizes the two longest isoforms.

Immunogen

MMP9 antibody was raised against a 16 amino acid peptide near the center of human MMP9. The immunogen is located within amino acids 260 - 310 of MMP9 .

Clonality

Polyclonal

Tissue Specificity

Produced by normal alveolar macrophages and granulocytes.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology

Purification

MMP9 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

78458 MW

Gene Name Synonym

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Prediction Reactivity

Rabbit, Bovine

Protein Name

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Isotype

IgG

Contents

MMP9 Antibody is supplied in PBS containing 0.02% sodium azide.