Anti-Cyclin-dependent kinase 4 Cdk4 Antibody — image 1 of 2

Product details

Anti-Cyclin-dependent kinase 4 Cdk4 Antibody

Catalog number A00159

Price for A00159

Size / count 100 µL

About this product

Boster Bio Anti-Cyclin-dependent kinase 4 Cdk4 Antibody catalog # A00159. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A00159
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Cyclin-dependent kinase 4;2.7.11.22; Cell division protein kinase 4; PSK-J3; CDK4
Gene Name: CDK4
UniProt: P11802
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein
Clonality: Polyclonal
Applications: WB, ICC, IF, IP
Purification: ProA affinity purified
Concentration: 1 mg/mL
Form: Liquid
Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 33730 MW
Gene Name Synonym: Cyclin-dependent kinase 4
Subcellular Location: Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G (1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G (1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Protein Name: Cyclin-dependent kinase 4
Contents: Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Frequently Asked Questions

What is the catalog number for Anti-Cyclin-dependent kinase 4 Cdk4 Antibody?

The catalog number for Anti-Cyclin-dependent kinase 4 Cdk4 Antibody is A00159.

What sizes are available for Anti-Cyclin-dependent kinase 4 Cdk4 Antibody?

Anti-Cyclin-dependent kinase 4 Cdk4 Antibody is available in the following size(s): 100 µL.

Is Anti-Cyclin-dependent kinase 4 Cdk4 Antibody in stock?

Anti-Cyclin-dependent kinase 4 Cdk4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Cyclin-dependent kinase 4 Cdk4 Antibody?

The safety data sheet for Anti-Cyclin-dependent kinase 4 Cdk4 Antibody is available here: https://www.bosterbio.com/msds?sku=A00159.

What is Anti-Cyclin-dependent kinase 4 Cdk4 Antibody used for?

Boster Bio Anti-Cyclin-dependent kinase 4 Cdk4 Antibody catalog # A00159. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.