Anti-MAPK14 Antibody (Y323)

About this product

Boster Bio Anti-MAPK14 Antibody (Y323) (Catalog # A00176-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00176-1-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Synonyms

Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a, MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Gene Name

MAPK14

UniProt

Q16539

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-330 amino acids from human MAPK14.

Clonality

Polyclonal

Tissue Specificity

Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney

Applications

WB, Flow Cytometry

Field of Research

T Cells, TLR Signaling, Signal Transduction, Neuroscience, Immunology, Cell Biology, Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

41293 Da

Subcellular Location

Cytoplasm. Nucleus

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.