Anti-CD80 Antibody

About this product

Boster Bio Anti-CD80 Antibody (Catalog # A00196) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00196

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) . Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1) . Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2) .

Synonyms

CD80 molecule, B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1

Gene Name

CD80

UniProt

P33681

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

CD80 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human CD80. The immunogen is located within amino acids 60 - 110 of CD80.

Clonality

Polyclonal

Applications

ELISA, WB, IF

Field of Research

Cell Cycle, Cancer, Immunology

Purification

CD80 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Storage Conditions

CD80 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

33048 MW

Gene Name Synonym

CD80 molecule

Subcellular Location

Membrane; Single-pass type I membrane protein.

Prediction Reactivity

Rabbit

Protein Name

CD80 molecule

Isotype

IgG

Contents

CD80 Antibody is supplied in PBS containing 0.02% sodium azide.