Anti-TSC2 (phospho-S939) Antibody

About this product

Boster Bio Anti-TSC2 (phospho-S939) Antibody catalog # A00229S939. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00229S939

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Gene Name

TSC2

UniProt

P49815

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human TSC2 around the phosphorylation site of Ser939.

Clonality

Polyclonal

Tissue Specificity

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059) . May also play a role in microtubule-mediated protein transport (By similarity) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

200608 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Tuberin

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

Protein Name

Tuberin

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2