Anti-Autophagy protein 5 ATG5 Antibody

About this product

Boster Bio Anti-Autophagy protein 5 ATG5 Antibody (Catalog # A00240) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00240

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3) -like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.

Synonyms

ASP, APG5, APG5L, hAPG5, APG5-LIKE

Gene Name

ATG5

UniProt

A9UGY9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.

Immunogen

ATG5 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human ATG5. The immunogen is located within the first 50 amino acids of ATG5.

Clonality

Polyclonal

Tissue Specificity

Expressed in bone marrow and testis and neutrophils.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Autophagy

Purification

ATG5 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Storage Conditions

ATG5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

22048 MW

Gene Name Synonym

ATG5 autophagy related 5 homolog (S. cerevisiae)

Subcellular Location

Secreted .

Prediction Reactivity

Bovine, Pig

Protein Name

ATG5 autophagy related 5 homolog (S. cerevisiae)

Isotype

IgG

Contents

ATG5 Antibody is supplied in PBS containing 0.02% sodium azide.