Anti-FoxO3A (phospho-S253) Antibody

About this product

Boster Bio Anti-FoxO3A (phospho-S253) Antibody catalog # A00252S253. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A00252S253

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Forkhead box protein O3 ; AF6q21 protein

Gene Name

FOXO3

UniProt

O43524

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthetic phosphopeptide derived from human FOXO3A around the phosphorylation site of Serine 253.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106) . Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882) . Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882) . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

71277 MW

Gene Name Synonym

Forkhead box protein O3

Subcellular Location

Cytoplasm, cytosol

Protein Name

Forkhead box protein O3

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2