Anti-PAX6 Antibody (Center)

About this product

Boster Bio Anti-PAX6 Antibody (Center) (Catalog # A00273-1) . Tested in WB, Flow Cytometry, IF, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

A00273-1-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

PAX6 is paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription.

Synonyms

Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2

Gene Name

PAX6

UniProt

P26367

Host

Rabbit

Reactivity

Human

Immunogen

This PAX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-210 amino acids from the Central region of human PAX6.

Clonality

Polyclonal

Tissue Specificity

[Isoform 1]: Expressed in lymphoblasts.

Applications

WB, Flow Cytometry, IF, IHC-P

Field of Research

Developmental Biology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

46683 Da

Subcellular Location

Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}

Prediction Reactivity

Bovine, Mouse, Rat, Xenopus

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.