Anti-CHEK2 Antibody (N-term) — image 1 of 5

Product details

Anti-CHEK2 Antibody (N-term)

Catalog number A00277-1-80ul

Price for A00277-1-80ul

Size / count 80 µL

About this product

Boster Bio Anti-CHEK2 Antibody (N-term) (Catalog # A00277-1) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number: A00277-1-80ul
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.
Synonyms: Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2, CHEK2, CDS1, CHK2, RAD53
Gene Name: CHEK2
UniProt: O96017
Host: Rabbit
Reactivity: Human
Immunogen: This CHEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2.
Clonality: Polyclonal
Tissue Specificity: High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues
Applications: WB, IF, Flow Cytometry, IHC-P
Field of Research: Cancer
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Function: 25361978
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight: 60915 Da
Subcellular Location: [Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell [Isoform 7]: Nucleus. [Isoform 12]: Nucleus.
Isotype: Rabbit IgG
Contents: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-CHEK2 Antibody (N-term)?

The catalog number for Anti-CHEK2 Antibody (N-term) is A00277-1-80ul.

What sizes are available for Anti-CHEK2 Antibody (N-term)?

Anti-CHEK2 Antibody (N-term) is available in the following size(s): 80 µL.

Is Anti-CHEK2 Antibody (N-term) in stock?

Anti-CHEK2 Antibody (N-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-CHEK2 Antibody (N-term)?

The safety data sheet for Anti-CHEK2 Antibody (N-term) is available here: https://www.bosterbio.com/msds?sku=A00277-1.

What is Anti-CHEK2 Antibody (N-term) used for?

Boster Bio Anti-CHEK2 Antibody (N-term) (Catalog # A00277-1) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.