Anti-IFNAR1 Antibody (Center)

About this product

Boster Bio Anti-IFNAR1 Antibody (Center) (Catalog # A00306) . Tested in WB, Flow Cytometry, IHC-P-Leica application (s) . This antibody reacts with Human.

Specifications

Catalog number

A00306-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

IFNAR1 is the receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha-and beta-subunits themselves.

Synonyms

Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR

Gene Name

IFNAR1

UniProt

P17181

Host

Rabbit

Reactivity

Human

Immunogen

This IFNAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-188 amino acids of human IFNAR1.

Clonality

Polyclonal

Tissue Specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN- alpha resistant myeloma cell line U266R.

Applications

WB, Flow Cytometry, IHC-P-Leica

Field of Research

Cancer, Immunology, Signal Transduction, TLR Signaling, Inflammation, Lysosome

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

63525 Da

Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Late endosome. Lysosome. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.