Anti-Interferon regulatory factor 4 IRF4 Antibody

About this product

Boster Bio Anti-Interferon regulatory factor 4 IRF4 Antibody (Catalog # A00401) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00401

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.

Synonyms

MUM1, LSIRF, NF-EM5, MUM1, Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor, IRF-4

Gene Name

IRF4

UniProt

Q15306

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

IRF4 antibody is predicted to not cross-react with other IRF protein family members. IRF4 often migrates at a higher than predicted molecular weight in SDS-PAGE.

Immunogen

IRF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human IRF4. The immunogen is located within the last 50 amino acids of IRF4.

Clonality

Polyclonal

Tissue Specificity

Lymphoid cells.

Applications

ELISA, WB, ICC, IF

Field of Research

Innate Immunity

Purification

IRF4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8 (+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity) .

Storage Conditions

IRF4 antibody can be stored at 4 °C, stable for one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

51772 MW

Gene Name Synonym

Interferon regulatory factor 4

Subcellular Location

Nucleus.

Protein Name

Interferon regulatory factor 4

Isotype

IgG

Contents

IRF4 Antibody is supplied in PBS containing 0.02% sodium azide.