Anti-Toll-like receptor 1 TLR1 Antibody

About this product

Boster Bio Anti-Toll-like receptor 1 TLR1 Antibody (Catalog # A00429) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A00429

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.

Synonyms

TIL, CD281, rsc786, TIL. LPRS5, KIAA0012, Toll-like receptor 1, TIL

Gene Name

TLR1

UniProt

Q15399

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

TLR1 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TLR1. The immunogen is located within amino acids 160 - 210 of TLR1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Innate Immunity

Purification

TLR1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852) . Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211) . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Storage Conditions

TLR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

90291 MW

Gene Name Synonym

Toll-like receptor 1

Subcellular Location

Cell membrane

Protein Name

Toll-like receptor 1

Isotype

IgG

Contents

TLR1 Antibody is supplied in PBS containing 0.02% sodium azide.