Anti-Lamin A/C (phospho-S22) LMNA Antibody

About this product

Boster Bio Anti-Lamin A/C (phospho-S22) LMNA Antibody catalog # A00438S22. Tested in WB, IP applications. This antibody reacts with Human, Rat.

Specifications

Catalog number

A00438S22

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Prelamin-A/C; Lamin-A/C;70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1

Gene Name

LMNA

UniProt

P02545

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthetic phosphorylated peptide around S22 of human Lamin A (NP_005563.1) .

Clonality

Polyclonal

Tissue Specificity

In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.

Applications

WB, IP

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513) . Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980) . Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585) . Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

74139 MW

Gene Name Synonym

Prelamin-A/C

Subcellular Location

Nucleus

Protein Name

Prelamin-A/C

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2