Anti-IL-21 Antibody

About this product

Boster Bio Anti-IL-21 Antibody (Catalog # A00459) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00459

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

Synonyms

Za11, IL-21, Interleukin-21, Za11

Gene Name

IL21

UniProt

Q9HBE4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.

Immunogen

Anti-IL-21 antibody was raised against a peptide corresponding to 15 amino acids near the center of human IL-21 precursor. The immunogen is located within the last 50 amino acids of IL-21.

Clonality

Polyclonal

Tissue Specificity

Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

Applications

ELISA, WB, IHC-P

Field of Research

Chemokines, Cytokines, Cancer

Purification

IL-21 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG (1) and IgG (3) in B-cells (By similarity) . May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Storage Conditions

IL-21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

17923 MW

Gene Name Synonym

Interleukin 21

Subcellular Location

Secreted

Prediction Reactivity

Bovine, Pig

Protein Name

Interleukin 21

Isotype

IgG

Contents

IL-21 Antibody is supplied in PBS containing 0.02% sodium azide.