Anti-OPA1 Antibody

About this product

Boster Bio Anti-OPA1 Antibody catalog # A00508. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00508

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Dynamin-like 120 kDa protein, mitochondrial;3.6.5.5

Gene Name

OPA1

UniProt

O60313

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein

Clonality

Polyclonal

Tissue Specificity

Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.

Applications

WB, ICC, IF, IHC, Flow Cytometry

Purification

Store at +4°C after thawing. Aliquot store at -20°C or -198°C. Avoid repeated freeze / thaw cycles.

Concentration

1 mg/mL

Form

Liquid

Function

Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876) . Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429) . Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555) . The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555) . Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity) . Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity) . Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

111631 MW

Gene Name Synonym

Dynamin-like 120 kDa protein, mitochondrial

Subcellular Location

Mitochondrion inner membrane

Protein Name

Dynamin-like 120 kDa protein, mitochondrial

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2