Anti-GATA3 Antibody

About this product

Boster Bio Anti-GATA3 Antibody (Catalog # A00593) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00593

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

GATA3 is a zinc finger transcription factor that was first recognized as a possible determinant of T cell development. Later studies demonstrated that it is expressed in trophoblast giant cells and regulates trophoblast-specific genes during development. Specifically, GATA3 is selectively expressed in the trophectoderm of the peri-implantation embryo and regulates CDX2, which is required for the transcriptional repression of the POU5F1/Oct4 and NANOG genes and is thus essential for the segregation of the inner cell mass and trophectoderm at the blastocyst stage. Decreased or null-expression expression of GATA3 has also been suggested to play a major role in the development and progression of luminal breast cancer.

Synonyms

HDR, HDRS, Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3

Gene Name

GATA3

UniProt

P23771

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

GATA3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GATA3. The immunogen is located within amino acids 340 - 390 of GATA3.

Clonality

Polyclonal

Tissue Specificity

T-cells and endothelial cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis, Stem Cells

Purification

GATA3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.

Storage Conditions

GATA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

47916 MW

Gene Name Synonym

GATA binding protein 3

Subcellular Location

Nucleus.

Prediction Reactivity

Bovine, Chicken, Pig

Protein Name

GATA binding protein 3

Isotype

IgG

Contents

GATA3 Antibody is supplied in PBS containing 0.02% sodium azide.