Anti-PAI-1 SERPINE1 Antibody

About this product

Boster Bio Anti-PAI-1 SERPINE1 Antibody catalog # A00637. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00637

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Plasminogen activator inhibitor 1; PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1; SERPINE1; PAI1, PLANH1

Gene Name

SERPINE1

UniProt

P05121

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human PAI-1. AA range:266-315

Clonality

Polyclonal

Tissue Specificity

Expressed in endothelial cells (PubMed:2430793, PubMed:3097076) . Found in plasma, platelets, and hepatoma and fibrosarcoma cells.

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774) . Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU) . As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461) . As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705) . Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821) . It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027) . It is involved in cellular and replicative senescence (PubMed:16862142) . Plays a role in alveolar type 2 cells senescence in the lung (By similarity) . Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

45060 MW

Gene Name Synonym

Plasminogen activator inhibitor 1

Subcellular Location

Secreted

Protein Name

Plasminogen activator inhibitor 1

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.