Anti-Protein jagged-1 JAG1 Antibody

About this product

Boster Bio Anti-Protein jagged-1 JAG1 Antibody (Catalog # A00640) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00640

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1) . Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2) . JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3) . JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5) .

Synonyms

Jagged 1, AGS, AHD, AWS, CD339, HJ1, JAGL1

Gene Name

JAG1

UniProt

P78504

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms.

Immunogen

JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is located within the last 50 amino acids of JAG1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle, Stem Cells

Purification

JAG1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614) . May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510) . Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity) . Enhances fibroblast growth factor-induced angiogenesis (in vitro) .

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

133799 MW

Gene Name Synonym

Jagged 1

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Jagged 1

Isotype

IgG

Contents

JAG1 antibody is supplied in PBS containing 0.02% sodium azide.