Anti-MMP14 Antibody (N-term)

About this product

Boster Bio Anti-MMP14 Antibody (N-term) (Catalog # A00656) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00656-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.

Synonyms

Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14

Gene Name

MMP14

UniProt

P50281

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.

Clonality

Polyclonal

Tissue Specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Applications

WB, Flow Cytometry, IHC-P

Field of Research

Cancer, Cardiovascular, Cell Biology, Metabolism, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

208374841271465722330140

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

65894 Da

Subcellular Location

Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV Forms a complex with BST2 and localizes to the cytoplasm

Prediction Reactivity

Bovine, Pig

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.