Anti-p68 RNA Helicase (phospho-Y593) DDX5 Antibody

About this product

Boster Bio Anti-p68 RNA Helicase (phospho-Y593) DDX5 Antibody catalog # A00670Y593. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00670Y593

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Probable ATP-dependent RNA helicase DDX5;3.6.4.13; DEAD box protein 5; RNA helicase p68; DDX5; G17P1, HELR, HLR1

Gene Name

DDX5

UniProt

P17844

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide derived from human p68 RNA Helicase around the phosphorylation site of Y593.

Clonality

Polyclonal

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

69148 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Probable ATP-dependent RNA helicase DDX5

Subcellular Location

Nucleus, nucleolus

Protein Name

Probable ATP-dependent RNA helicase DDX5

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2