Anti-Sex hormone-binding globulin SHBG Antibody

About this product

Boster Bio Anti-Sex hormone-binding globulin SHBG Antibody (Catalog # A00682) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00682

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers (1) . Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes (2,3) . Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus (4) .

Synonyms

Sex hormone-binding globulin, ABP, SBP, TEBG

Gene Name

SHBG

UniProt

P04278

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.

Immunogen

SHBG antibody was raised against a 16 amino acid peptide near the center of human SHBG. The immunogen is located within amino acids 220 - 270 of SHBG.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 2 are present in liver and testis.

Applications

ELISA, WB, IF

Field of Research

Obesity

Purification

SHBG antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

43779 MW

Gene Name Synonym

Sex hormone-binding globulin

Subcellular Location

Secreted . In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. .

Prediction Reactivity

Rabbit

Protein Name

Sex hormone-binding globulin

Isotype

IgG

Contents

SHBG antibody is supplied in PBS containing 0.02% sodium azide.