Anti-POT1 Antibody

About this product

Boster Bio Anti-POT1 Antibody catalog # A00696. Tested in WB, IHC applications. This antibody reacts with Human, Monkey.

Specifications

Catalog number

A00696

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein; POT1

Gene Name

POT1

UniProt

Q9NUX5

Host

Rabbit

Reactivity

Human, Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'- TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

71442 MW

Gene Name Synonym

Protection of telomeres protein 1

Subcellular Location

Nucleus

Protein Name

Protection of telomeres protein 1

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.